Allergic reaction to Croscarmellose sodium used as excipient of a generic drug
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منابع مشابه
Allergic reaction to Croscarmellose sodium used as excipient of a generic drug.
Croscarmellose sodium is a very commonly used pharmaceutical additive approved by the US Food and Drug Administration. It is used in injectable preparations as a suspending agent to promote solubilization of compounds with poor water solubility; it is also present in tablets as binder, glidant and antiadherent, in bulk laxatives as active principle and as an additive in food products. Croscarme...
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Allergic reactions to mannitol have been reported rarely, despite its widespread use as a drug and as a food excipient. This is the first case report in which oral mannitol induces an immediate type hypersensitivity as a drug excipient, in a 42 year old man affected by rhinitis to olive tree pollen. Unusual and undervalued risk factors for mannitol hypersensitivity are examined.
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Copyright © 2014 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. pISSN 1226-3303 eISSN 2005-664...
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Background Because of its rarity, drug excipients allergy is often unsuspected by the doctors. Some times the active drug is blamed and discontinued unnecessarily when the real culprit is drug excipients. This was suspected when patients reported exacerbation of urticaria with anti histaminic which are actually used for treating urticaria. After suspecting drug excipient as the cause of allergy.
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ژورنال
عنوان ژورنال: QJM
سال: 2010
ISSN: 1460-2725,1460-2393
DOI: 10.1093/qjmed/hcq175